Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands a.j.bredenoord@amsterdamumc.nl. Department of Medicine, Division of Gastroenterology and Hepatology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA. Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Instituto de Investigación Sanitaria Princesa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Hospital General Tomelloso, Tomelloso, Spain. Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. Regeneron Pharmaceuticals Inc, Tarrytown, New York, USA. Sanofi, Bridgewater, New Jersey, USA.